a tool for identifying drug-targetable redox-active disulphides

Venom-like beta-defensin

Intramolecular

Cysteine 40 and cysteine 54

A redox-regulated disulphide may form within Venom-like beta-defensin between cysteines 40 and 54 (16 and 30 respectively in this structure).

Details

Redox score ?

86

PDB code

Structure name

structure of platypus 'intermediate' defensin-like peptide (int-dlp)

Structure deposition date

2014-03-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

53

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

40

Residue number B

54

Peptide name

Venom-like beta-defensin

Ligandability

Cysteine 40 of Venom-like beta-defensin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 54 of Venom-like beta-defensin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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